A clinical-stage biotechnology company headquartered in the Bay Area is seeking a highly motivated Senior Research Associate, Cancer Biology (CrispR) to support in vitro oncology drug discovery efforts. This role is focused on hands-on experimental work using cancer cell line models to evaluate compound activity, investigate mechanism of action (MoA), and support pharmacodynamic (PD) biomarker development. You will work within a collaborative team to advance early-stage oncology programs through rigorous in vitro biology.

Industry: Discovery and Development
Location: South San Francisco, CA
Compensation: $55 - $70 per hour (based upon experience)

What You’ll Do:

Design and execute in vitro, cell-based assays using cancer cell lines to support oncology drug discovery programs
Investigate mechanism of action (MoA) of compounds through functional and molecular assays
Develop and optimize assays to evaluate compound efficacy, target engagement, and pathway modulation
Culture and maintain a variety of human cancer cell lines under sterile conditions
Perform assays including:
Cell viability and proliferation (e.g., CellTiter-Glo, IncuCyte, clonogenic assays)
Protein and gene expression (Western blot, qPCR, ELISA)
Contribute to pharmacodynamic (PD) biomarker identification and validation in cancer cell systems
Analyze and interpret experimental data, and communicate findings clearly to project teams
Troubleshoot and optimize assays to ensure reproducibility and data quality
Collaborate cross-functionally to support project progression in a fast-paced research environment

Qualifications:

B.S. with 5+ years of M.S with 3+ years of industry experience in cancer biology or oncology drug discvoery (will not consider PhD level candidates)
Strong hands-on experience with in vitro cancer cell biology, specifically working with established cancer cell lines
Proven experience developing and executing cell-based assays in cancer models
Demonstrated experience supporting mechanism of action (MoA) studies
Experience with pharmacodynamic (PD) biomarker assays (e.g., protein or gene expression readouts)
Proficiency in standard molecular and cellular biology techniques, including Western blot, qPCR, and ELISA
Experience with gene perturbation approaches (CRISPR, siRNA, shRNA) in cancer cell systems
Ability to independently design, execute, and troubleshoot experiments

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Estimated Min Rate: $55.00
Estimated Max Rate: $70.00

What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:

Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
Health Savings Account (HSA) (for employees working 20+ hours per week)
Life & Disability Insurance (for employees working 20+ hours per week)
MetLife Voluntary Benefits
Employee Assistance Program (EAP)
401K Retirement Savings Plan
Direct Deposit & weekly epayroll
Referral Bonus Programs
Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

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Yoh, A Day & Zimmermann Company

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Senior Research Associate, Cancer Biology (CrispR)