Associate Director of Biologics
Onsite

Associate Director for the Expression Sciences team within Therapeutics Discovery. The Associate Director will lead a team of scientists to express complicated proteins, engineer mammalian cells, upstream processes, and deliver creative research solutions to formidable drug discovery challenges. The scientific leader will have expertise in protein expression, molecular biology and biochemistry. Working with multispecific antibodies and antibody drug conjugates. The Associate Director will lead a team of scientists to express complicated proteins, engineer mammalian cells, upstream processes, and deliver research solutions to drug discovery challenges

Responsibilities:
Lead and mentor a team responsible for expressing candidate biotherapeutic molecules in stable mammalian cell culture systems.
As a protein expression expert, interpret complex datasets to identify and mitigate risks as part of our discovery process. Creatively identify drug developability trends by modeling large datasets.
Identify value-adding protein production capabilities, industry trends, and emerging technologies and work to evaluate these. Lead creative research efforts (e.g. using omics and screens) to maximize efficiency and maintain our organizational competitiveness.
Collaborate across our company s global functions to Client medicines. Communicate regularly and accurately within the department and with company leadership to drive rapid, impactful decision making.
Lead drug discovery projects and research initiatives, ensuring alignment with the company s strategic goals.
Prepare and present reports, proposals, and primary data to senior management and partners. Coordinate and present timelines and deliverables with a wide range of partners and stakeholders.

Qualifications:
Education: A minimum Ph.D. in molecular biology, biochemistry, cell biology or similar field with a minimum of 6 years of pharmaceutical industry experience is required.

Skills/Experience:
Evidence of people management of multiple personnel is required. Included in this is experience with coaching development plans, payroll, and hiring.
Expertise in molecular biology including cloning approaches, RNA seq, ATAC-seq, ChIP-seq, or CRISPR mutagenesis is highly sought after.
Recombinant protein expression expertise is required, including hands-on experience with methods like mammalian cell culture (CHO & HEK293), transfection, and bioreactors.
Practical experience purifying recombinant proteins using Akta systems with affinity chromatography, IEX, HIC, and MMC is preferred.
Experience with analytical methods such as HPLC, CE-SDS, SDS PAGE, BLI, and proteomic approaches is strongly preferred.
Expertise with big data modeling and bioinformatics is especially desired.
Excellent interpersonal skills, both written and verbal, with the ability to convey nuanced information clearly to senior management is required.
Experience working on multiplexed teams is preferred.
Proficiency with electronic notebooks (ELN), databases and laboratory information management systems (LIMS) is strongly preferred.

Kaztronix

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Associate Director of Biologics