Biohub is leading the new era of AI-powered biology to cure or prevent disease through its 501c3 medical research organization, with the support of the Chan Zuckerberg Initiative.

The Team

The Biohub in Chicago is an independent nonprofit research institute that brings together three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to make breakthroughs in medicine and develop new technologies, frequently in collaboration with our partner universities. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

We pursue large scientific challenges that cannot be pursued in conventional environments
We enable individual investigators to pursue their riskiest and most innovative ideas
The technologies developed at Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

Biohub's Chicago location is seeking a motivated and detail-oriented Scientist to support functional immunogenomics research focused on CRISPR-based screening and single-cell technologies. This role provides hands-on exposure to advanced genome engineering technologies, cell-based assays, and disease-relevant model systems, offering a strong foundation in translational research practices. The successful candidate will support ongoing research efforts within the group by contributing to CRISPR screens, CRISPR-based validation studies, generating high-quality and reproducible experimental data, and assisting with research activities that may inform translational discoveries.

What You'll Do

Perform CRISPR screens in disease-relevant models.
Assist in model development and maintenance, including culture and differentiation of iPSCs or other relevant cell systems that recapitulate disease-related phenotypes.
Perform and optimize single-cell-based assays to assess functional consequences of genetic perturbations.
Conduct in vivo studies in murine models to validate CRISPR screen candidate hits.
Maintain detailed lab notebooks, document experimental outcomes, and present results.

What You'll Bring

PhD or MSc degree in Biological Sciences, Biochemistry, or a related discipline.
5 or more years of hands-on lab experience in mammalian cell culture, single cell library preparations, and standard molecular biology techniques.
Hands-on experience with flow cytometry, single cell library preparation, including sample preparation and basic data analysis and interpretation.
Ability to handle murine models independently and perform basic procedures like tail vein, spleen collection, and IP injections
Strong organizational skills and the ability to follow experimental SOPs precisely.
Ability to work independently on assigned projects.
Based on the experience of the qualified candidate, the starting role will be either a senior RA or scientist.

Compensation

The Chicago, IL base pay range for a new hire in this role is $103,000 - $141,900. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.

Benefits for the Whole You

We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.

Provides a generous employer match on employee 401(k) contributions to support planning for the future.
Paid time off to volunteer at an organization of your choice.
Funding for select family-forming benefits.
Relocation support for employees who need assistance moving

If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

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Biohub

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