Position Summary:
We are seeking a driven, laboratory-focused PhD scientist to join a high-priority program aimed at dissecting mechanisms of cancer biology using advanced cellular and molecular techniques. The role requires technical fluency, strong analytical thinking, and a commitment to rigorous experimentation. The successful candidate will work closely with a dynamic team to unravel the mechanistic underpinnings of a novel therapeutic target and to advance our small-molecule discovery efforts. This is an exciting opportunity to contribute to foundational biology in support of a pioneering cancer biology discovery program. Position level will be commensurate with experience.

What you’ll do:

Independently design, execute, and troubleshoot in vitro experiments to interrogate target function, pathway modulation, and drug mechanism of action
Perform cellular assays involving gene perturbation (siRNA/shRNA, CRISPR), overexpression systems, and pharmacologic perturbations
Apply a variety of molecular and cellular techniques to investigate cell signaling, trafficking, immune-relevant phenotypes, and synthetic lethal dependencies
Generate and interpret high-quality data, with a strong emphasis on quantitative rigor, reproducibility, and mechanistic insight
Interface closely with the project team to align experimental approaches with translational and therapeutic objectives
Present findings clearly and regularly in cross-functional meetings and contribute to the strategic evolution of the program

Requirements:

PhD in cancer biology, molecular biology, cell biology, genetics or a related discipline; 4-5+ years of postdoctoral or industry (preferred) experience
Deep expertise in tumor biology, including cancer genomics, cancer cell biology, exploitation of cancer vulnerabilities (synthetic lethality) and oncogenic signaling
Demonstrated ability to drive hypothesis-driven research at the bench with minimal supervision
Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods
Expertise in mammalian tissue culture, cell-based viability and proliferation assays, and multi-parametric flow cytometry
Hands-on experience with gene expression (qRT-PCR, RNA prep), protein analysis (Western blot, ELISA, HTRF, MSD), microscopic analyses (confocal), and functional genomics screens
Experience developing and optimizing mechanistic assays to explore protein function, degradation, trafficking, or immune signaling is highly desirable
Ability to think critically, synthesize data across platforms, and communicate clearly across diverse scientific audiences
Familiarity with computational tools for data analysis and visualization is a plus
Previous experience working with CROs or external collaborators is a plus

Nice-To-Haves

Intellectual curiosity and scientific rigor balanced with a practical, execution-first mindset
Energized by fast-paced, discovery-stage science in a highly collaborative environment
Flexible, adaptable, and comfortable with scientific ambiguity and iteration
Strong communicator who thrives in a matrixed team and contributes to a culture of accountability, inclusion, and scientific excellence

Pay: From $70.00 per hour

Benefits:

Dental insurance
Free parking
Health insurance
Vision insurance

Application Question(s):

What types of in vitro cancer biology assays have you independently designed, executed, and troubleshot?
What is your experience with mammalian tissue culture, viability/proliferation assays, and pathway modulation studies?
Have you used siRNA, shRNA, CRISPR, or overexpression systems to interrogate target function?
Do you have hands-on experience with qRT-PCR, RNA prep, Western blot, ELISA, HTRF, MSD, flow cytometry, and confocal microscopy?
Have you worked on synthetic lethality, cancer vulnerabilities, oncogenic signaling, or functional genomics screens?
Have you supported small-molecule drug discovery or mechanism-of-action studies?

Work Location: In person

Beacon Hill Life Sciences

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