Lead, Cancer Biology Research and Therapeutics, Disease Mechanism Research

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Purpose and Scope:

The Disease Mechanism Research team is seeking an exceptional scientific leader versed in state-of-the art methods in oncology research. The ideal candidate should demonstrate deep understanding of cancer biology and provide scientific direction for pre-clinical research in Astellas’ Cancer Biology team. The successful candidate will lead a diverse team of scientists to build a deeper understanding of cancer biology in focused cancer indications and advance the Astellas oncology pipeline.

Essential Job Responsibilities:

Expert knowledge of tumor biology, including cancer cell intrinsic and extrinsic mechanisms leading to disease progression and maintenance
Provide extensive expertise in cancer biology, including model and assay development to support preclinical drug development
Establish key in vitro and ex vivo immuno-oncology assays and models suitable for therapeutic evaluation and mechanistic investigation across the Astellas portfolio
Mentor and support a team of junior researchers to address mechanisms of action and resistance to cancer therapies
Contribute to program development through broad expertise in oncogenic signaling pathways
Manage multiple projects simultaneously and act as a project lead to effectively collaborate cross-functionally with colleagues across the Astellas organization
Effectively communicate with team members to efficiently conduct experiments, articulate experimental details and results with other members of the Astellas research organization, and present research findings and recommendations to senior leadership

Qualifications Required:

PhD and post-doctoral training in cancer biology, cancer immunotherapy or a closely related fields with a minimum of 7+ years postdoctoral experience in an academic or industry setting
Experience and strong interest in cancer therapy and/or immuno-oncology research
Demonstrated expertise in solid tumor biology and tumor model development
Proven ability to drive innovative research strategies and deliver results
Recognized leadership in mentoring talent, establishing best practices, and ensuring experimental rigor
Excellent verbal, written, and interpersonal communication skills are essential
Strong work ethic with a dedicated mindset of proactively identifying and productively filling gaps

Preferred:

Understanding of novel modalities in cancer therapeutics including but not limited to targeted protein degradation, ADC and bispecific T cell engager platforms
Knowledge of methodologies employed in tumor metabolism researchExperience in multicellular in vitro models

Working Environment:

This position is based in South San Francisco (West Coast Innovation Center) and will require on-site work.

Salary Range : $140,000 - $220,000 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations)

Benefits :

Medical, Dental and Vision Insurance
Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
401(k) match and annual company contribution
Company paid life insurance
Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
Long Term Incentive Plan for eligible positions
Company fleet vehicle for eligible positionsReferral bonus program

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Lead, Cancer Biology Research and Therapeutics, Disease Mechanism Research